The following statement(s) is/are true concerning hepatic blood flow
belongs to book: ASIR SURGICAL MCQs BANK|Dr. Gharama Al-Shehri|1st edition| Chapter number:7| Question number:101
All Answers
total answers (1)
belongs to book: ASIR SURGICAL MCQs BANK|Dr. Gharama Al-Shehri|1st edition| Chapter number:7| Question number:101
total answers (1)
a. Although constituting only 2.5% of total body weight, the liver receives 25% of the cardiac output
c. The liver serves as a physiologic blood reservoir either releasing blood back into the systemic circulation at times of acute blood loss or in situations of volume overload serving as a site of extra blood storage
d. An important function of the liver is to filter particulate debris which is performed by phagocytic Kupffer cells which line the hepatic sinusoidal endothelium
The liver constitutes about 2.5% of the total body weight but receives 25% of the cardiac output. Total hepatic blood flow is 100 to 130 ml/min/kg. About two-thirds of total hepatic blood flow is derived from the portal vein and one-third from the hepatic artery. The liver also serves as a physiologic blood reservoir. About 25% to 30% of the liver volume is accounted for by blood, and in cases of acute blood loss up to 30%, or as much as 300 ml of the hepatic blood volume can be released into the systemic circulation without adverse effects on liver function. Conversely, in the case of right heart failure or other causes of systemic volume overload, as much as one liter of extra blood can be stored in the liver before passive congestion and liver injury occur. The hepatic sinusoids are lined by an endothelium punctuated with pores that allow proteins and other particles to diffuse out of the vascular tree and into proximity with hepatocytes. This extreme permeability of the liver allows rapid exchange of a diverse number of nutrients, hormones and environmental agents between the blood and the hepatocyte. The liver also acts as a filter for particulate debris, which enters the portal circulation through intestinal capillaries. Particles such as bacteria are ingested by Kupffer cells by the process of phagocytosis. Kupffer cells line the hepatic sinusoidal endothelium where formed blood elements and matter may be in direct contact with these phagocytic cells.
need an explanation for this answer? contact us directly to get an explanation for this answer