Q:

Which of the following statement(s) relating to chronic pancreatitis is/are correct?

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Which of the following statement(s) relating to chronic pancreatitis is/are correct?


  1. In the United States, the most common cause of chronic pancreatitis is alcohol abuse
  2. Approximately 50% of chronic alcoholics develop chronic pancreatitis
  3. Clinically significant chronic pancreatitis develops on average after five years of alcohol abuse in men
  4. The risk of alcohol-induced chronic pancreatitis can be decreased by consumption of a high-protein diet

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a. In the United States, the most common cause of chronic pancreatitis is alcohol abuse

In the United States, alcohol consumption is the major cause of chronic pancreatitis: with approximately 70% of cases attributable to this factor. Most patients with symptomatic chronic pancreatitis have consumed large volumes of alcohol daily for a prolonged period of time. The average daily intake of alcohol is 150 to 175 g with the mean duration of alcoholism before recognition of pancreatitis being 18 years for men and 11 years for women. The incidence of chronic pancreatitis on autopsy studies of chronic alcoholics is 50 times the rate of non-drinking controls. Only 10% of alcoholics develop chronic pancreatitis—suggesting that factors other than long-term alcohol exposure may also influence susceptibility. In both experimental and clinical studies, the risk of alcohol-induced chronic pancreatitis is increased by a high-protein, high-fat diet.

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