Pancreatic exocrine secretory products include a bicarbonate-rich electrolyte solution as well as digestive enzymes. Which of the following statement(s) is/are true?

A. Cholecystokinin (CCK) is the most potent endogenous stimulant of pancreatic enzyme secretion.

B. The chloride and bicarbonate concentrations of pancreatic juice vary and depend on the secretory flow rate

C. Secretin is the most potent endogenous stimulant of pancreatic water and electrolyte secretion.

DISCUSSION: CCK is the most potent endogenous stimulant of pancreatic enzyme secretion. The pancreatic acinar cells respond to CCK with release of their zymogen granules into the ductal system. Peptidases are released in inactive form, later to be activated by contact with duodenal enterokinase and activated trypsin. Secretin is the most potent endogenous stimulant of pancreatic water and electrolyte secretion. The concentrations of the anions bicarbonate and chloride vary and are largely dependent on the secretory flow rate stimulated by secretin.