A 58-year-old male undergoes resection of a Dukes C2 colon cancer via right hemicolectomy. Three years postoperatively, rising CEA levels prompt evaluation including abdominal computed tomography

d. 25–30%

The liver is the most frequent site of blood-borne metastases from primary colorectal cancers. In a subgroup of patients, the liver may be the only site of recurrent disease, and surgical excision of these metastases is the only curative option for these patients. Overall, surgical resection is associated with a 25% to 30% 5-year survival rate. Patients eligible for hepatic resection of metastatic disease are those who have no evidence of extrahepatic tumor, no medical contraindications for surgery, and less than four lesions that are amenable to resection with negative surgical margins.