Which statements about anorectal Crohn's disease are true?

A. It may be the only overt manifestation of Crohn's disease

B. It accompanies large intestine Crohn's more often than small-intestine Crohn's.

E. It may subside in response to metronidazole, 250 mg. q.i.d.

DISCUSSION: Anorectal Crohn's disease may be the sole gross manifestation of Crohn's disease. It more often accompanies large-intestinal Crohn's than small-intestinal Crohn's. When present with small-intestinal Crohn's, resection of the small-intestinal disease does not affect the course of the anorectal disease. The anorectal disease may subside with metronidazole therapy alone, but local conservative therapy, such as draining abscesses or unroofing anal fistulas, may also relieve symptoms and promote healing.