Q:

Which of the following statements regarding intrinsic factor is/are correct?

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Which of the following statements regarding intrinsic factor is/are correct?


  1. Intrinsic factor is produced in chief cells located in the gastric fundus
  2. Total gastrectomy is followed by folate deficiency due to vitamin malabsorption secondary to intrinsic factor deficiency
  3. Intrinsic factor secretion, like that of acid, is stimulated by gastrin, histamine, and acetylcholine
  4. Intrinsic factor deficiency accompanies H pylori-caused antral gastritis

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c. Intrinsic factor secretion, like that of acid, is stimulated by gastrin, histamine, and acetylcholine

The gastric mucosa is the site of production of intrinsic factor, which is a necessary co-factor for the absorption of vitamin B12 by the ileal mucosa. Total gastrectomy and atrophic gastritis involving the proximal oxyntic mucosa are regularly followed by vitamin B12 deficiency, manifest as pernicious anemia. Acid-secreting parietal cells are the site of intrinsic factor synthesis. Like acid secretion, intrinsic factor secretion is stimulated by gastrin, histamine, and acetylcholine 

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