Q:

Which of the following statements concerning the pathology of gastric cancer is true?

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Which of the following statements concerning the pathology of gastric cancer is true?


  1. Distal gastric cancers are becoming more common.
  2. Intestinal-type gastric tumors resemble colon carcinomas and have a better prognosis than diffuse type
  3. Early gastric cancers are confined to the mucosa and are lymph node negative.
  4. Broders\' histologic grading system correlates well with survival: patients with grade IV tumors have 5-year survival rates around 65%.

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B. Intestinal-type gastric tumors resemble colon carcinomas and have a better prognosis than diffuse type

DISCUSSION: Distal gastric cancers are decreasing in incidence in several populations. Lesions of the gastroesophageal junction and cardia have increased in incidence over the past two decades. Early gastric cancers are confined to the mucosa and submucosa of the stomach. Six to 10% of these early lesions are lymph-node positive. The survival rates from early gastric cancer is related to node positivity, just as in advanced gastric cancer. Broders' histologic grades do correlate well with survival. Grade I and IV tumors are associated with a 65% and 11% 5-year survival, respectively. The Lauren classification system is divided into intestinal and diffuse-type tumors. The intestinal-type tumor is more analogous to colon carcinoma and has a better prognosis than the diffuse type. 

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