Q:

All of the following contribute to peptic ulcer disease except:

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All of the following contribute to peptic ulcer disease except:


  1. Cigarette smoking
  2. Nonsteroidal anti-inflammatory drugs.
  3. Helicobacter pylori.
  4. Gastrinoma.
  5. Spicy foods.

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E. Spicy foods.

DISCUSSION: Cigarettes and nonsteroidal anti-inflammatory drugs are common contributors to peptic ulceration. H. pylori is found in most patients with peptic ulceration, and eradication of this bacterium decreases the recurrence rate for peptic ulcer disease. Gastrinoma results in much acid secretion and commonly presents with peptic ulcer disease. Dietary factors such as spicy foods have little or no effect on postprandial acid secretion and do not contribute to peptic ulceration.

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