All of the following measures have been recommended for control of acid secretion in patients with ZollingerEllison syndrome except:

A. Antrectomy.

DISCUSSION: Patients with MEN 1 syndrome or sporadic-metastatic Zollinger-Ellison syndrome should be palliated with omeprazole to control their acid secretion. Patients who undergo exploration may have a variety of operations to control their ulcer diathesis, including total gastrectomy or various vagotomy-type operations. Antrectomy alone is not indicated, since the gastrin that is contributing to the production of acid is not coming from the antrum but coming from the tumor.