Q:

All of the following statements about gastrin-releasing peptide (GRP) are true except:

waelhammad
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2022-12-07
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All of the following statements about gastrin-releasing peptide (GRP) are true except:

  1. In species other than man and dog GRP is commonly referred to as bombesin.
  2. GRP serves as a neurotransmitter
  3. GRP inhibits pancreatic secretion when given intravenously
  4. GRP stimulates gastric acid secretion when given intravenously
  5. GRP is released in response to cholinergic stimulation of the parietal cells to stimulate release of gastrin.
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waelhammad
2022-12-07
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C. GRP inhibits pancreatic secretion when given intravenously

DISCUSSION: Gastrin-releasing peptide and bombesin are homologous peptides of different amino acid lengths. GRP functions as a neurotransmitter at the cholinergic nerve ending on the parietal cell and releases gastrin after cholinergic stimulation. It functions to increase gastric acid secretion and also pharmacologically increases pancreatic secretion.

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