Q:

All the following are true of omeprazole except:

waelhammad
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2022-12-07
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All the following are true of omeprazole except:

  1. It is the only drug available that has the potential to achieve pharmacologically induced achlorhydria.
  2. It works by blocking the hydrogen-potassium ATPase in the parietal cell.
  3. It is parietal cell specific.
  4. It has a short half-life (about 90 minutes) when taken orally.
  5. It has been associated with gastric neoplasm in a rat model.
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waelhammad
2022-12-07
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D. It has a short half-life (about 90 minutes) when taken orally.

DISCUSSION: Omeprazole and drugs in this category are the only drugs that can produce achlorhydria. All other antiacid drugs reduce acid secretion without producing achlorhydria. Omeprazole inhibits acid at the final common pathway by blocking the hydrogen-potassium ATPase in parietal cells. It is gastric parietal cell specific and has a very long half-life, allowing once daily dosing when given orally. When it was given to rats in pharmacologic doses the gastric mucosa formed carcinoid-type tumors. This problem has not been identified in humans. 

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