Which of the following statement(s) meet the criteria for organ failure?

a. Bilirubin greater than 5 mg/dl

b. Creatinine greater than 3 mg/dl

c. Alveoloarterial O2 gradient greater than 300 mm Hg

d. Glasgow Coma score less than 10

Multiple organ failure is defined by dysfunction of two or more of the six vital organ systems: cardiovascular, respiratory, nervous system, renal, liver, and host defenses.