Wound contraction and ultimate contracture may be controlled by which of the following drugs?

A. Colchicine.

C. Thiphenamil (Trocinate).

DISCUSSION: Wound contraction is carried out by highly specialized cells called myofibroblasts, which, as their name implies, have histologic characteristics of fibroblasts and smooth muscle cells. The activity of these cells, and therefore wound contraction, can be influenced by topical application of smooth muscle inhibitors such as thiphenamil. Inhibitors of microtubule formation in myofibroblasts, such as colchicine and vinblastine, also inhibit wound contraction under experimental conditions. Glucocorticoids and NSAIDs do not affect the wound contraction process.