Q:

Which of the statements listed below about bleeding disorders is/are correct?

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Which of the statements listed below about bleeding disorders is/are correct?


  1. Acquired bleeding disorders are more common than congenital defects.
  2. Deficiencies of vitamin K decrease production of factors II, VII, IX, and X, protein C, and protein S.
  3. Hypothermia below 32؛C rarely causes a bleeding disorder.
  4. Von Willebrand\'s disease is a very uncommon congenital bleeding disorder.

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A. Acquired bleeding disorders are more common than congenital defects.

B. Deficiencies of vitamin K decrease production of factors II, VII, IX, and X, protein C, and protein S.

DISCUSSION: Acquired bleeding disorders are significantly more common than congenital bleeding defects. Vitamin K deficiency may be related to malnutrition or competitive inhibition of the production of the vitamin K–dependent factors II, VII, IX, X, protein C, and protein S by warfarin (Coumadin). Hypothermia causes significant platelet dysfunction with a significant bleeding disorder in many patients. It is among the least recognized causes of altered coagulation in surgical patients. Von Willebrand's disease is a relatively common disorder of bleeding and is generally undetectable by routine screening methods

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