Q:

Which of the following statements about respiratory acidosis are true?

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Which of the following statements about respiratory acidosis are true?


  1. Compensation occurs by a shift of chloride out of the red blood cells
  2. Renal compensation occurs rapidly.
  3. Retention of bicarbonate and increased ammonia formation are normal compensatory mechanisms.
  4. Narcotic administration is an unusual cause of respiratory acidosis.
  5. The ratio of bicarbonate to carbonic acid is less than 20:1.

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C. Retention of bicarbonate and increased ammonia formation are normal compensatory mechanisms.

E. The ratio of bicarbonate to carbonic acid is less than 20:1.

DISCUSSION: Renal compensation for acute hypoventilation is relatively slow. Depression of the respiratory center by morphine can lead to respiratory acidosis. Renal retention of bicarbonate, ammonia formation, and shift of chloride into red cells combine to increase the ratio of bicarbonate to carbonic acid to 20:1.

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