Q:

First endocrine influence in 2ry sexual characters:

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First endocrine influence in 2ry sexual characters:


  1. Secretion of delta-4 Androstenedione from the adrenal gland
  2. Pineal body maturation
  3. Pituitary maturation
  4. Hypothalamic down regulation???

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d. Hypothalamic down regulation???

NB: “The beginning of puberty is caused by a decrease in high gonadostate sensibility to prepubertal levels of sexual steroids. What produces this change and timing is still unknown. However, it seems that the adrenal (delta-4 Androstenedione) as well as the pineal may play an important role.” Pubmed Downregulation dec steroid sensitivity + feedback  

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