Q:

How would you investigate a case of primary hyperparathyroidism on follow-up?

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A young female of 24 years, presents with bony pains and difficulty in walking for 2 years. Her plain radiographs show fractures of right shaft of tibia and fibula and diffuse osteopenia. Screw and plating was seen at right femur for which patient gives a past history of fracture due to trivial trauma 3 years back. Her biochemical parameters reveal serum Ca 13.4 mg/dL, serum phosphorus 1.4 mg/dL, serum creatinine 1.2 mg/dL. Hb is 11.0 g%. 25(OH)D value is 45 ng/dL and her PTH is 108 pg/mL. USG abdomen shows left renal calculus. BMD shows severe osteoporosis. Her past history reveals being treated for 6 months for pulmonary tuber- culosis 4 years back. Her mother expired from non-Hodgkin’s lymphoma 12 years back.

How would you investigate a case of primary hyperparathyroidism on follow-up?

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Serums calcium           Biannually

Serum creatinine         Annually

Bone mineral density    Annually

Initially                           24 hour urinary Ca

                                      Creatinine clearance

                                        Abdominal X-ray + USG 

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