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What is different in FHH from primary hyperparathyroidism?

waelhammad
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2022-11-19
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A 54-year-old female presents with drowsiness to the emergency. Her BP is 140/90 mm of Hg with pulse after rate 100/minute. Her investigations reveals serum creatinine 2.4 mg/dL, Na 140 mEq/L, K 4.3 mEq/L. Complete blood count (CBC) and liver function test (LFT) is normal. CT scan head is normal. Her past evaluation reveals a cervical lymph node fine needle aspiration cytology (FNAC) suggestive of granulomatous inflammation. Her bone marrow examination is suggestive of non-Hodgkin’s lymphoma.

What is different in FHH from primary hyperparathyroidism?

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waelhammad
2022-11-19
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Familial hypocalciuric hyprcalcemia (FHH) is often detectable in affected members of the kindred in the first decade of life. PTH values are usually lower for the same degree of calcium elevation than in patients with primary hyperparathyroidism. Renal calcium reabsorption is >99% (↓ 24 hour urinary Ca). Hypocalciuria persists even after parathyroid surgery, i.e. hypocalciuria is not PTH dependent.

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