Q:

What is the role of PTH?

waelhammad
Save to bookmark
|
2022-11-19
|
  79 
0

A 54-year-old female presents with drowsiness to the emergency. Her BP is 140/90 mm of Hg with pulse after rate 100/minute. Her investigations reveals serum creatinine 2.4 mg/dL, Na 140 mEq/L, K 4.3 mEq/L. Complete blood count (CBC) and liver function test (LFT) is normal. CT scan head is normal. Her past evaluation reveals a cervical lymph node fine needle aspiration cytology (FNAC) suggestive of granulomatous inflammation. Her bone marrow examination is suggestive of non-Hodgkin’s lymphoma.

What is the role of PTH?

Medicine, textbook solutions, Medicine textbook-solutions,
login and add your own answer to this question

All Answers

waelhammad
2022-11-19
need an explanation for this answer? contact us directly to get an explanation for this answer

Parathyroid hormone (PTH) is an 84-amino acid single chain peptide. The amino acid portion PTH (1-34) is critical for its biologic action. It is secreted as preproparathyroid hormone (115 aa) → Proparathyroid hormone (90 aa) (aa, amino acid).

Actions of PTH

PTH                  Increases rate of dissolution of bone mineral

                       Renal action: ↑ reabsorption of Ca (distal tubule)

                   Inhibition of phosphate transport (proximal tubule)

                   Stimulation of 25(OH)D 1α-hydroxylase Inhibits 24-hydroxylase

Receptors for PTH    PTH1R Responds to PTH and PTHrP

                                   PTH2R Responds to PTH only

PTH-related peptide (PTHrP) is secreted by some squamous cell tumors.

It is also secreted by mammary tissue (secreted into milk).

Decreased PTH release and synthesis occurs by:

• Calcium (ionized form) acting through CaSR (hypercalcemia)

• 1,25(OH)2D

• Hypermagnesemia

• Severe hypomagnesemia.

need an explanation for this answer? contact us directly to get an explanation for this answer

total answers (1)

Similar questions

need a help?

find thousands of online teachers now