Q:

What is the role of vitamin D in bone metabolism?

waelhammad
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2022-11-19
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A 54-year-old female presents with drowsiness to the emergency. Her BP is 140/90 mm of Hg with pulse after rate 100/minute. Her investigations reveals serum creatinine 2.4 mg/dL, Na 140 mEq/L, K 4.3 mEq/L. Complete blood count (CBC) and liver function test (LFT) is normal. CT scan head is normal. Her past evaluation reveals a cervical lymph node fine needle aspiration cytology (FNAC) suggestive of granulomatous inflammation. Her bone marrow examination is suggestive of non-Hodgkin’s lymphoma.

What is the role of vitamin D in bone metabolism?

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waelhammad
2022-11-19
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1,25(OH)2D → Stimulates 24a-hydroxylase

Inhibits 1α-hydroxylase

1α-hydroxylase is present in:

• Proximal tubular cells of kidney

• Epidermal keratinocytes

• Trophoblastic layer of placenta

• Granulomas of sarcoidosis, TB, berylliosis

• Site for vitamin D receptors include intestine, pancreas, bone, skeletal

muscle, kidney, vascular smooth muscle, skin (epidermal keratinocytes), lymphocytes. Not in liver.

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