A 25-year-old unmarried girl comes to the endocrinology OPD with history of amenorrhea for past 7 months. Her menarche happened at the age of 13 years. She has no other complaints except for mild lethargy or fatigue. She has no known endocrinological problem. She complains of some occasional episodes of sweating and palpitations. She has no complaints of headache or any visual disturbances. She has no complaints of vomiting or any change in weight. She does not give any history of any drug intake. She has not taken any treatment for amenorrhea till now. She has not undergone any gynecological procedures till now. Prior to seven months, her menses were regular. Her mother is concerned about her amenorrhea as she is getting married next month and her future conception prospects. Her height is 160 cm and her predicted height is 158 cm. Her weight is 60 kg. She has normal secondary sexual characters development. She has no features of virilization. She has no similar history in the family and she has no hirsutism or acne. She has no galactorrhea.
What is premature ovarian failure?
Premature ovarian failure (POF) is an early ovarian malfunction different from menopause, which disturbs production of follicles resulting in amenorrhea under the age of 40 in 1–3% of reproductive age women. About 10–28% of the patients experience primary amenorrhea and about 4–18% show secondary amenorrhea. Affected women show menstrual problems followed by an elevated level of gonadotropins [follicle stimulating hormone (FSH) ≥40 IU/L] and hypoestrogenism for an average four months.
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