Q:

What is Technetium 99 scan? Is it the same as radioiodine?

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A 30-year-old woman presents with complaints of palpitations, tremulousness and weight loss of around 4 kg (despite a good appetite) over the last 2 months. On examination, she is anxious, has a pulse rate of 100/min, warm and moist peripheries, fine tremors of the outstretched hands and a visible goiter. No obvious abnormalities in the eyes. Her last menstrual period was 15 days ago. Her primary care physician orders for laboratory examination which reveals normal hemogram with an erythrocyte sedimentation rate of 25 mm in the first hour. Thyroid stimulating hormone (TSH) <0.001 mIU/L and total T4 28 mg/dL. A diagnosis of thyrotoxicosis is made. She is started on beta-blockers and she is asked to get a technetium uptake scan and review.

What is Technetium 99 scan? Is it the same as radioiodine?

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Both are molecules that are rapidly taken up by the sodium iodine symporter (NIS) in the thyroid gland. Technetium offers the advantage of imaging in 20 min, lesser radiation exposure and easier accessibility as compared to 123I. Thus, in the differential diagnosis of thyrotoxicosis, more centers are using technetium than radioiodine.

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