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A LJ 3-year-old female patient is referred for evaluation of leukocytosis which has been present for the last 3 years. Complete blood shows leukocyte count of 1 7 .000. hemoglobin 1 LJ.3 g/dl. and platelet count 390.000/JLL. Physical exam shows no lymph- adenopathy or hepatosplenomegaly. Other than a long history of tobacco abuse. the patien t has no significant medical problems. The peripheral blood smear is shown below.
The patient is diagnosed with persistent polyclonal B-cell lymphocytosis (PPBL). Which of the following is true regarding this condition?
- Binucleated lympocytes are a rare finding; smoking cessation leads to resolution of the lymphocytosis
- Binucleated lymphocytes are a common finding; smoking cessation does not lead to resolution of the lymphocytosis
- Binucleated lymphocytes are a common finding; smoking cessation leads to resolution of the lymphocytosis
- Binucleated lymphocytes are a rare finding; smoking cessation does not lead to resolution of the lymphocytosis
Medicine
B. Binucleated lymphocytes are a common finding (making up l .S% to 9% of lympho-cytes). Smoking cessation does not lead to resolution of the lymphocytosis (Br J Haematol. 1999; 104: 486-493).
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