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A 32 -year-old female patien t presen ts with fatigue and dyspnea. She appears pale, but has an otherwise normal physical examination. Complete blood cou nt shows leukocyte count 1 95 .000/,LLL. hemoglobin 6.8 g/dl, and platelet count 1 0.000/,LLL. The periph- eral blood smear is shown below.
What clinical scenario is associated with AML with inv(l6)?
- Young patient with extramedullary myeloid sarcoma
- Elderly patient with massive splenomegaly
- Young patient with abdominal lymphadenopathy
- Elderly patient with renal failure due to tumor lysis syndrome
Medicine
A. AML with inv(l 6) may be associated with extramedullary involvement and indeed has been reported in 10% to 20% of patients. Chemotherapy and radiation may be used in the manage-ment of extramedullary AML. The prognostic significance of extramedullar AML is not well defined (!CO. 1 995; 1 3(7):1800-1 8 16, Blood. 201 1; 118(14):3785-3793).
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