Q:

What findings on the peripheral blood smear would be consistent with a diagnosis of acute my- eloid leukemia?

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A 32 -year-old female patien t presen ts with fatigue and dyspnea. She appears pale, but has an otherwise normal physical examination. Complete blood cou nt shows leukocyte count 1 95 .000/,LLL. hemoglobin 6.8 g/dl, and platelet count 1 0.000/,LLL. The periph- eral blood smear is shown below.

What findings on the peripheral blood smear would be consistent with a diagnosis of acute my-eloid leukemia?


  1. Absent nucleoli, coarse chromatin, stains positive for peroxidase
  2. Prominent nucleoli, coarse chromatin, stains positive for peroxidase
  3. Absent nucleoli, fine chromatin, negative peroxidase staining
  4. Prominent nucleoli, fine chromatin, stains positive for peroxidase

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D. AML blasts have prominent nucleoli and fine chromatin and may stain positive for peroxidase.

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