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A 57-year-old man presents with fatigue and dyspnea on exertion. Initial laboratory workup shows hemoglobin 1 0.5 g/dl with an MCV of 85 fl. leukocyte count 11 .2 00/ .uL. and platelet count 1 67 ,000/ .uL. No lymphadenopathy or splenomegaly was noted on mphysical exam. Peripheral blood smear is shown below.
What comorbid condition is not found with an increased incidence in patients diagnosed with LGL leukemia?
- Rheumatoid arthritis (RA)
- Immune thrombocytopenia
- Hepatitis C
- Celiac disease
- Focal segmental glomerulosclerosis (FSGS)
Medicine
E. Both autoimmune conditions (most commonly RA) and infectious diseases (including HIV, hepatitis C, EBV, and CMV) are associated with LGL leukemia. There is no association between FSGS and LGL leukemia. (Blood. 20 1 1;117(10): 2764-2774)
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