0
A 57-year-old man presents with fatigue and dyspnea on exertion. Initial laboratory workup shows hemoglobin 1 0.5 g/dl with an MCV of 85 fl. leukocyte count 11 .2 00/ .uL. and platelet count 1 67 ,000/ .uL. No lymphadenopathy or splenomegaly was noted on physical exam. Peripheral blood smear is shown below.
Flow cytometry in this patient would typically reveal what results?
- Positive CDS, CD19, CD20, and CD23
- Positive for CD3, CDS, and CD57
- Positive for CDS, CD19, and CD20 but negative for CD23
- Positive for CD38 and CD138
Medicine
B. Peripheral blood smear shows several large granular lymphocytes. T-cell large granularm lymphocytic leukemia (T-LGL) is usually positive for the CD markers 3, 8, 16, and 57. Choice A would be consistent with chronic lymphocytic leukemia. Choice C is the immunophenotype of natural killer cell lymphocytosis, and choice D shows markers characteristic of plasma cells. T-cell receptor gene rearrangement was positive in the patient, confirming the diagnostic impression ofLGL.
need an explanation for this answer? contact us directly to get an explanation for this answer