A 2 3-year-old female patien t presen ts wi th com plai n ts of "spots on my legs ." She has been in her normal state of health recen tly with the exception of cold symptoms that las ted for 5 days and have now resolved . Complete blood count shows hemoglobin of 1 LJ.5g/dl. leukocyte count of 8.900/,LLL. and platelet count of 1 3 ,000/,LLL. Photographs of the patient and her peripheral blood smear are shown below.

The peripheral blood smear in a patient with immune thrombocytopenia would most likely dem-onstrate which of the following abnormal findings?
- Rouleaux formation
- Large platelets
- Schistocytes
- Howell-Jolly bodies
- Nucleated red blood cells
B. The peripheral smear of a patient with ITP may show large platelets, consistent with a bone marrow response of accelerated platelet release. Rouleaux is seen commonly in multiple my-eloma, schistocytes in TTP and Howell- Jolly bodies in splenectomized patients or those with hemo-lytic or megaloblastic anemia, and nucleated red blood cells in conditions of hemolysis or marrow replacement.
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