Q:

In determining eligibility for hematopoietic stem cell transplantation in a patient with MM, which of the following would be considered a possible reason for exclusion from transplant?

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A 79-year-old Caucasian man presents with a chief complaint of back pain. Hemoglo bin is 9.7 g/dl. leukocyte count 7.600/Jll. and platelet count 21 LJ,OOO/fll. BUN is 26 mg/dl. creatinine 2.1 mg/dl. total protein 9.0 g/dl. albumin 3.1 g/dl. and calcium 10.9 mg/dl. The images below show the bone marrow aspirate and a skull film from the skeletal survey.I

n determining eligibility for hematopoietic stem cell transplantation in a patient with MM, which of the following would be considered a possible reason for exclusion from transplant? 


  1. ECOG performance status 2
  2. Serum creatinine of 4 mg/dL, not on dialysis
  3. Age> 65
  4. History of ischemic stoke
  5. Failed > 2 lines of treatment

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B. NYHA stage III/IV heart failure, direct bilirubin> 2.0 mg/dL, ECOG PS 3 or 4, age more than 77 years, and serum creatinine > 2.5 unless the patient is established on dialysis are common exclusion criteria used when evaluating patients for HSCT. 

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