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A 79-year-old Caucasian man presents with a chief complaint of back pain. Hemoglo bin is 9.7 g/dl. leukocyte count 7.600/Jll. and platelet count 21 LJ,OOO/fll. BUN is 26 mg/dl. creatinine 2.1 mg/dl. total protein 9.0 g/dl. albumin 3.1 g/dl. and calcium 10.9 mg/dl. The images below show the bone marrow aspirate and a skull film from the skeletal survey.
What chromosome abnormality is not commonly found in patients with MM?
- t(l1;14)(ql3;q32)
- 13q 14 deletion
- t(4;14)(p16;q32)
- Trisomy 12
- 17p13 deletion
Medicine
D. Cytogenetic abnormalities have been detected by FISH in 80% or more of patients with MM. Deletion 13q is the most common abnormality, reported in 40% to 50% of newly diagnosed patients using FISH. The prevalence oft(ll;14) is 15% to 20%; t(4;14) is 15%; and 17p deletion is 5% to 10%. Trisomy 12 has been reported in association with lymphomas and chronic lymphocytic leukemia.
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