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A 30-year-old female patient is seen for evaluation of fatigue. Initial labs show a hemo globin of 7.6 g/dl, MCV of 106 FL. WBC of 3,200/,LLL. and platelets of 178.000/,LLL. LDH is 1 .200 U/L and haptoglobin is low. On review of symptoms, she states that her urine is dark in the morning, but clears toward the evening. Test tubes showing serial urine samples are shown below.
Which of the following is a serious potential adverse effect of eculizumab?
- Hepatic failure
- Pericardia! effusion leading to tamponade
- Meningococcal infection
- Reactivation of latent hepatitis B
- Acute closed-angle glaucoma
Medicine
C. Eculizumab binds to CS and blocks the terminal complement sequence. Patients lacking the terminal complement proteins, CS to C9, are at risk for Neisseria infections. Vaccination against Neisseria meningitides is recommended prior to therapy with this agent.
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