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A 30-year-old female patient is seen for evaluation of fatigue. Initial labs show a hemo globin of 7.6 g/dl, MCV of 106 FL. WBC of 3,200/,LLL. and platelets of 178.000/,LLL. LDH is 1 .200 U/L and haptoglobin is low. On review of symptoms, she states that her urine is dark in the morning, but clears toward the evening. Test tubes showing serial urine samples are shown below.
PNH is not associated with which of the following conditions?
- Development of aplastic anemia
- Evolution to acute myeloid leukemia
- Severe IgG deficiency
- Spontaneous thrombosis of the portal vein
- Hemorrhage due to severe thrombocytopenia
Medicine
C. PNH is associated with both evolution to aplastic anemia (AA) and, in some cases, devel opment of acute myeloid leukemia (AML) in 1% to 2% of cases. Patients with PNH are at increased risk of both venous thrombosis and hemorrhage. PNH is not associated with immunoglobulin deficiency.
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