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A 2-week old infant is referred for further evaluation after workup revealed leukocyte count of 120.000/,LLL. hemoglobin 7.2 g/dl, and platelet count 8.000/,LLL. Flow cytom etry reveals increased expression of CD13, CD19. CD20. and CD33. Peripheral blood smear is shown.
What is the most common cytogenetic abnormality in MPAL?
- t(9;22)
- 11q23 translocation
- t(4;11)
- Complex karyotype
- t(8;14)
Medicine
A. Philadelphia chromosome was detected in 20% of cases ofMPAL. Translocations involv ingthe mixed lineage leukemia gene (MLL) at 11q23 are seen in 8% of cases (Blood. 2011;117(11):3163).
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