0
A 2-week old infant is referred for further evaluation after workup revealed leukocyte count of 120.000/,LLL. hemoglobin 7.2 g/dl, and platelet count 8.000/,LLL. Flow cytom etry reveals increased expression of CD13, CD19. CD20. and CD33. Peripheral blood smear is shown.
What is the most likely diagnosis?
- Chronic myeloid leukemia (CML)
- Chronic lymphocytic leukemia (CLL)
- Mixed phenotype acute leukemia (MPAL)
- Acute myeloid leukemia (AML)
- Acute lymphoblastic leukemia (ALL)
Medicine
C. Peripheral slide reveals the presence of two populations of blasts: one with large cells with high nuclear to cytoplasmic ratio, dispersed chromatin, and prominent nucleoli, and another population with small cells with nucleoli and less dispersed chromatin. Flow cytometry reveals expres sion of both myeloid and lymphoid markers. This is characteristic of MPAL, a condition that com prises less than 5% of acute leukemia cases and is usually associated with a poor prognosis (Leukemia. 2010;24(11):1844, Leukemia. 2010;24(7):1392, Blood. 2011;117(11):3163).
need an explanation for this answer? contact us directly to get an explanation for this answer