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A 57-year-old female is admitted to the hospital secondary to weakness , fatigue, and anorexia. Physical exami nation discloses massive splenomegaly with no evidence of lymphadenopathy or hepatomegaly. Laboratory workup reveals leukocyte count of 27LJ,OOO/fLL, hemoglobin of 8.2 g/dl, and platelet count of 85,000/fil. Flow cytom-etry shows i ncreased popu lation of cells expressing CD 1 9, CD20, and su rface lgM.Expression of CDS and C02 3 is absen t. Peripheral blood smear is shown below.
What is the most common chromosomal abnormality in cases of B-PLL?
- del(1 7p)
- t(1 1; 14)
- del(1 1 q)
- t(14;1 8)
- del(Sq)
Medicine
A. Deletions of chromosome 1 7p affecting p53 locus is seen in more than 50% of B-PLL cases. Presence of t(1 1; 14) indicates the presence of MCL in leukemic phase, while t(14;1 8) is charac-
teristic of but not diagnostic of follicular lymphoma (Blood. 1 997;89(6)2015, Br J Haematol. 2004;125(3):330).
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