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A LJ7 -year-old male presen ts for further evaluation secondary to worsening fatigue of 2 weeks' duration . Laboratory evaluation reveals elevated leukocyte count at LJ 7 .000/ ,LLL. hemoglobin of 1 0.3 g/dl. platelet count of 67.000/,LLL. and LDH of 2.300/,LLL. Peripheral blood smear is obtai ned and is shown below.
Patien t is admitted to the hospital. and bone marrow aspiration is obtained as shown below.
What is the most common chromosomal abnormality in Burkitt lymphoma/leukemia?
- t(1 1; 14)
- t(2;8)
- t(l4;18)
- t(8;14)
- t(8;22)
Medicine
D. t(8;14) involving the immunoglobulin heavy chain on chromosome 14 has been re-ported in 80% of BL cases and leads to overexpression of the oncogene c-MYC. Translocations involv-ing kappa and lambda light chains on chromosomes 2 and 22, respectively, are seen in 1 5% and 5% of cases (J Clin Oneal. 2000;18(21):3707, Proc Nat! Acad Sci USA. 1982;79(24):7824).
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