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A LJ9-year-old male presen ted for further evaluation secondary to weakness and fatigue. Physical examination revealed splenomegaly with no peripheral lymphadenopathy. Labo-ratory workup showed leukocyte count of 1 8 , 500/pl. hemoglobin of 9.3 g/dl. and platelet count of 11 Q.OOO/pl. Peripheral .blood smear is shown below.
What genetic test can be used to confirm the diagnosis?
- Testing for KIT mutations
- Testing for RAS mutations
- Testing for EGFR mutations
- Testing for ALK mutations
- Testing for BRAF mutations
Medicine
E. Mutations in BRAF have been detected in nearly 100% ofHCL cases and can be used as a diagnostic test to differentiate HCL from other lymphoproliferative disorders (NEJM. 201 1; 364(24):2305, Br J Haematol. 201 1; 155(5):609, Blood. 2012;1 19(1):188, Blood. 20 12;1 19(1):192).
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