Q:

What is the most likely diagnosis?

0

A 28-year-old female with no significant prior medical history presents For Further evalu-ation secondary to Fatigue. Physical examination reveals pal lor and splenomegaly. Labo-ratory workup shows leukocyte count of 76.000/JLL. hemoglobin 8.5 g/dl. and platelet count of 3Lj , OOO/JLL. Peripheral blood slide is shown below.

Peripheral blood flow cytometry reveals increased number of leukocytes positive For Tdl CD 1 0, and CD 19 .

What is the most likely diagnosis?


  1. Acute promyelocytic leukemia (APL)
  2. Chronic myeloid leukemia (CML)
  3. Chronic lymphocytic leukemia (CLL)
  4. B-cell acute lymphoblastic leukemia (B-ALL)
  5. T-cell acute lymphoblastic leukemia (T-ALL)

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D. Peripheral blood smear reveals the presence oflarge cells with fine chromatin and increased nuclear-to-cytoplasmic ratio with a thin rim of cytoplasm. These findings are compatible with the description of blasts. Flow cytometry is positive for B-cell markers confirming the diagnosis of B-ALL.

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