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A 67-year-old male presents for further evaluation secondary to persistent bleeding from a hyperpigmen ted lesion on the hard palate that had been biopsied 5 days previ-ously (shown below).
Patien t reports having good health with no sign i fican t prior medical h istory. Evaluation reveals leu kocyte count of 2.1 00/pl, ANC 800/pl, hemoglobin of 8.2/d l, and platelet count of 82 .000/ pl. PT and PTT are prolonged . I mages of the peripheral blood smear and bone marrow aspirate are shown below.
What are the characteristic flow cytometric findings in APL?
- CD1 3+, CD33+, CD34+, HLA-DR-
- CD1 3+, CD33-, CD34+, HLA-DR-
- CD13+, CD33+, CD34-, HLA-DR-
- CD1 3-, CD33-, CD34-, HLA-DR+
- CD1 3+, CD33+, CD34+, HLA-DR+
Medicine
C. Contrasting with other subtypes of AML, APL is characteristically negative for CD34 and HLA-DR. This can provide a quick and early clue to the underlying diagnosis (Blood.
2009;1 1 3(9): 1 875).
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