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A LJ8-year-old male presen ts to the emergency room for further evaluation of a 3-week history of progressively worsening Fatigue. Physical examination reveals pal lor and dif-Fuse petech iae over lower extremities. Laboratory evaluation shows a total leukocyte cou nt of 2 3, LJOO/,uL. hemoglobin 9.8 g/dl. and platelet count of 1 3, 000/,uL. Periph-eral blood smear and bone marrow aspirate are shown.
Which of the following scenarios meets the current WHO criteria for the diagnosis of AML?
- Bone marrow blast count of 8% with deletion Sq
- Bone marrow blast count of 16% with monosomy 7
- Bone marrow blast count of 6% with translocation t(8;21)
- Bone marrow blast count of 12% with translocation t(9;22)
- Bone marrow blast count of 1 8% with translocation t(8;14)
Medicine
C. The current WHO criteria defines AML as the presence of 20% or more blasts in the bone marrow or peripheral blood or the presence of any of the following chromosomal abnormalities regardless of the blast count, t(8;2 l ), t(l6;16), inv(l6), t(l5;17) (Blood. 2009;1 14(5):937).
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