What is the most common cytogenetic abnormality detected in CLL?
belongs to book: Hematology Case Review|Donald C. Doll & Radwan F. Khozouz & Wes Matthew Triplett|| Chapter number:1| Question number:3
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belongs to book: Hematology Case Review|Donald C. Doll & Radwan F. Khozouz & Wes Matthew Triplett|| Chapter number:1| Question number:3
total answers (1)
D. Chromosomal abnormalities are detected in 82% of CLL cases. Deletion 13q is seen in 45% to 55% of cases, deletion 1 1q in 18% to 20%, trisomy 12 in 1 5% to 1 6%, deletion 6q in 7%, and deletion 17p in 7% to 10% of de novo CLL cases (N Eng! J Med. 2000;343(26):1910, Blood. 1997;89(7):25 16). In addition, SF3B1 and other novel cancer genes have been reported in CLL. SF3B1 has been noted primar-ily with deletion 1 1q cases and is associated with a poor prognosis (N Eng! J Med. 201 1;365:2497-2506).
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