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A 7 LJ-year-old male with no sign i ficant medical history is referred by h is primary care physician For Further evaluation of generalized lymphadenopathy. Patient reports no preceding weigh t loss. n igh t sweats. or Fever. On physical examination. lymphade-nopathy and splenomegaly are Found. with the spleen edge pal pable 7 em below the left costal margi n. Laboratory workup reveals a total leu kocyte count of 36.500/pl. with the majority of cells of the type shown below. hemoglobin 1 LJ.S g/dl and a plate-let count of 3LJ2 .000/ pl.
What is the typical flow cytometric pattern seen in cases of CLL?
- CDS-, CD10+, CD19-, CD20+, CD23+
- CDS+, CD19+, CD20+, CD23-
- CDS+, CD19+, CD20+, CD23+
- CDS-, CD19+, CD20+, CD23+
- CDS-, CD19+, CD20+, CD23-
Medicine
C. CLL is characterized by expression of CDS, CD19, CD20 (dim), and CD23. Positivity for CD23 differentiates it from MCL, which is typically negative for CD23, and positivity for CDS differ-entiates it from other B-cell non-Hodgkin lymphomas (Blood. 2008;111(12):5446).
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