Q:

The most common cause of testicular feminization syndrome is

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The most common cause of testicular feminization syndrome is


  1. a 45,XO genotype
  2. a 47,XXY genotype
  3. inadequate production of testosterone and MIF
  4. congenital adrenal hyperplasia
  5. lack of androgen receptors

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E. The most common cause of testicular feminization syndrome is the lack of androgen receptors in the urogenital folds and labioscrotal swellings. Because these tissues lack androgen receptors, they are blind or unresponsive to androgens. Consequently, these tissues develop into female external genitalia even though the fetus has a 46,XY genotype.

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