Q:

A young insulin-dependent diabetic woman in her first pregnancy is concerned that her daily injection of insulin will cause a congenital malformation in her baby. What should the physician tell her?

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A young insulin-dependent diabetic woman in her first pregnancy is concerned that her daily injection of insulin will cause a congenital malformation in her baby. What should the physician tell her?


  1. Insulin is highly teratogenic; discontinue treatment
  2. Insulin does not cross the placental membrane
  3. Insulin crosses the placental membrane but is degraded rapidly
  4. Insulin will benefit her baby by increas- ing glucose metabolism
  5. Insulin crosses the placental membrane but is not teratogenic

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B. Insulin, like all protein hormones, does not cross the placental membrane in significant amounts.

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