Q:

Fetal sex can be diagnosed by noting the presence or absence of the Barr body in cells obtained from the amniotic fluid. What is the etiology of the Barr body?

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Fetal sex can be diagnosed by noting the presence or absence of the Barr body in cells obtained from the amniotic fluid. What is the etiology of the Barr body?


  1. Inactivation of both X chromosomes
  2. Inactivation of homologous chromosomes
  3. Inactivation of one Y chromosome
  4. Inactivation of one X chromosome
  5. Inactivation of one chromatid

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D. The Barr body is formed from inactivation of one X chromosome in a female. All somatic cells of a normal female will contain two X chromosomes. The female has evolved a mechanism for permanent inactivation of one of the X chromosomes presumably because a double dose of X chromosome products would be lethal.

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