A 61-year-old man, known smoker, comes to the hospital with complaints of painless hematuria, urgency and dysuria. He has been worried about his loss of weight and reduced general activity. Which investigation would be diagnostic of his condition?

The key is G. Cystoscopy with biopsy. [Painless hematuria in elderly man is due to Ca of bladder usually and in bladder cancer there are UTI like symptoms like urgency, dysuria. Also constitutional symptom like weight loss and reduced genral activity is feature of carinoma].