Q:

A 48 year old man presents with bone pain. Laboratory: ALP high, phosphate normal. What is the most likely diagnosis?

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A 48 year old man presents with bone pain. Laboratory: ALP high, phosphate normal. What is the most likely diagnosis?


  1. Osteoporosis
  2. Osteomalacia
  3. Paget’s disease
  4. Fx
  5. Myeloma

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The key is C. Paget’s disease. [Bone pain, high ALP and normal phosphate are suggestive of pagets disease. In osteoporosis Ca+, PO43- and ALP are normal. In osteomalacia Ca+ low, PO43- low and ALP is high. In Pagets disease Ca+ and PO43- normal and ALP markedly raised].

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