Q:

A 40 year old man with marked weight loss over the preceding 6months has bilateral white, vertically corrugated lesion on the lateral surfaces of the tongue. What is the single most likely diagnosis?

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A 40 year old man with marked weight loss over the preceding 6months has bilateral white, vertically corrugated lesion on the lateral surfaces of the tongue. What is the single most likely diagnosis?


  1. C1 esterase deficiency
  2. Crohns disease
  3. HIV disease
  4. Sarcoidosis
  5. Sjogren’s syndrome

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The key is C. HIV disease. [The lesion described is leukoplakia which is likely association of HIV disease].

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