Q:

A 38 year old lady presents with amenorrhea has very high LH and FSH levels, normal prolactin and low estradiol. Choose the single most likely diagnosis?

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A 38 year old lady presents with amenorrhea has very high LH and FSH levels, normal prolactin and low estradiol. Choose the single most likely diagnosis?


  1. PCOS (polycystic ovarian failure)
  2. POF (premature ovarian failure)
  3. Hypothyroidism
  4. Pregnancy
  5. Menopause

All Answers

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The key is B. POF. [High LH and FSH, normal prolactin and low estrogen in secondary amenorrhea in a lady under age 40 is highly suggestive of POF].

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