Q:

A young lady with primary amenorrhea has normal LH, FSH, estradiol and prolactin. Choose the single most likely diagnosis?

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A young lady with primary amenorrhea has normal LH, FSH, estradiol and prolactin. Choose the single most likely diagnosis?


  1. PCOS (polycystic ovarian syndrome)
  2. POF (premature ovarian failure)
  3. Absent uterus
  4. Absent ovaries
  5. Turner’s syndrome

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The key is C. Absent uterus. [Normal LH, FSH, estradiol and prolactin rule outs PCOS (increased LH, increased FSH, normal oestrogen. LH:FSH ratio is 2:1 or 3:1), POF (in POF, LH & FSH raised, FSH > 20 IU/L), Absent ovary will lead to low estradiol, high FSH and LH, Turner’s syndrome: gonadal streaks, as absent ovaries].

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